Scientific Research on Berberine

 

1. Yin, J., Xing, H., & Ye, J. (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. *Metabolism*, *57*(5), 712–717. [https://doi.org/10.1016/j.metabol.2008.01.013](https://doi.org/10.1016/j.metabol.2008.01.013)

 

2. Kong, W\.-J., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., ... & Wang, Y. (2004). Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. *Nature Medicine*, *10*(12), 1344–1351. [https://doi.org/10.1038/nm1135](https://doi.org/10.1038/nm1135)

 

3. Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., & Yu, W. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. *The Journal of Clinical Endocrinology & Metabolism*, *93*(7), 2559–2565. [https://doi.org/10.1210/jc.2007-2404](https://doi.org/10.1210/jc.2007-2404)

 

4. Zhang, H., Wei, J., Xue, R., Wang, S., Zhang, Z., Yin, P., & Liang, D. (2010). Lipid-lowering effect of berberine in human subjects and rats. *Biological & Pharmaceutical Bulletin*, *33*(12), 1812–1817. [https://doi.org/10.1248/bpb.33.1812](https://doi.org/10.1248/bpb.33.1812)

 

5. Turner, N., Li, J. Y., Gosby, A., To, S. W. C., Cheng, Z., Miyoshi, H., ... & Cooney, G. J. (2008). Berberine and its derivatives ameliorate glucose and lipid metabolism in vivo. *The Journal of Clinical Endocrinology & Metabolism*, *93*(12), 4672–4679. [https://doi.org/10.1210/jc.2008-0578](https://doi.org/10.1210/jc.2008-0578)

 

6. Xu, Y., Liu, L., Qu, Z., Shi, Z., Rui, Y., Zhang, J., & Hao, P. (2012). Berberine improves insulin resistance in hepatocytes by inhibition of fat deposition and endoplasmic reticulum stress. *Biochimie*, *94*(10), 2215–2223. [https://doi.org/10.1016/j.biochi.2012.06.018](https://doi.org/10.1016/j.biochi.2012.06.018)

 

7. Cicero, A. F. G., Baggioni, A., & Veronesi, M. E. (2016). Clinical efficacy and safety of berberine in the treatment of obesity and type 2 diabetes. *Frontiers in Pharmacology*, *7*, 839. [https://doi.org/10.3389/fphar.2016.00839](https://doi.org/10.3389/fphar.2016.00839)

 

8. Gao, X., Xu, L., Zhang, Y., & Sun, X. (2019). Effects of berberine on polycystic ovary syndrome: A systematic review and meta-analysis. *Journal of Ethnopharmacology*, *233*, 81–89. [https://doi.org/10.1016/j.jep.2018.12.009](https://doi.org/10.1016/j.jep.2018.12.009)

 

9. Wang, Q., Qi, L., Zhao, P., Jing, J., & Chen, B. (2016). Effect of berberine on nonalcoholic fatty liver disease: A randomized controlled clinical trial. *Chinese Journal of Integrative Medicine*, *22*(3), 206–212. [https://doi.org/10.1007/s11655-015-2115-x](https://doi.org/10.1007/s11655-015-2115-x)

 

10. Zhang, Q., Xiao, X., Li, M., Yu, M., Zhang, H., & Li, X. (2014). Berberine attenuates cardiac dysfunction in diabetic cardiomyopathy via the AMPK signaling pathway. *Molecular and Cellular Endocrinology*, *402*, 40–47. [https://doi.org/10.1016/j.mce.2014.02.001](https://doi.org/10.1016/j.mce.2014.02.001)

 

11. Habtemariam, S. (2016). Berberine and inflammatory pathologies: A review of the evidence. *Phytotherapy Research*, *30*(11), 1721–1728. [https://doi.org/10.1002/ptr.5621](https://doi.org/10.1002/ptr.5621)

 

12. Raj, P., Alam, S., Biswas, S., & Ghosh, S. (2020). Berberine restores cognitive deficits in Alzheimer’s disease models by modulating amyloid pathology. *Journal of Neuroinflammation*, *17*(1), 1–12. [https://doi.org/10.1186/s12974-020-01938-3](https://doi.org/10.1186/s12974-020-01938-3)

 

13. Li, X., Yang, R., Zhao, Y., Bao, C., & Yang, M. (2017). Berberine ameliorates diabetic nephropathy in STZ-induced diabetic rats by inhibiting TGF-β1/Smad3 and NF-κB signaling pathways. *Journal of Ethnopharmacology*, *207*, 101–109. [https://doi.org/10.1016/j.jep.2017.05.034](https://doi.org/10.1016/j.jep.2017.05.034)

 

14. Wu, L., He, X., Lin, X., & Liu, Z. (2018). Protective effect of berberine against oxidative stress and mitochondrial dysfunction: A literature review. *Oxidative Medicine and Cellular Longevity*, *2018*, Article 1463547. [https://doi.org/10.1155/2018/1463547](https://doi.org/10.1155/2018/1463547)

 

15. Feng, X., Sun, Y., Fang, Y., & Chen, P. (2021). Pharmacokinetics and safety of berberine: A meta-analysis. *Journal of Clinical Pharmacy and Therapeutics*, *46*(3), 439–448. [https://doi.org/10.1111/jcpt.13323](https://doi.org/10.1111/jcpt.13323)

 

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